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Preheat oven to 350ºF.
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In a large bowl, beat cake mix, yogurt, 3 egg whites, and water until mixed well.
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Pour batter into a 9×13 inch baking dish; set aside.
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In a medium bowl, beat cream cheese until smooth.
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Gradually beat in powdered sugar on low speed.
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Add lemon zest and juice to cream cheese mixture and combine well.
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Take out 1/2 cup of the cream cheese mixture and place in refrigerator.
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Beat remaining 2 egg whites into cream cheese mixture on medium speed until blended.
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Pour cream cheese mixture evenly over the cake mixture.
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Bake cake for 25-30 minutes or until the middle is set; let cool completely.
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Spread reserved cream cheese mixture evenly over the cake.